منابع مشابه
Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation
Signaling through the T cell receptor (TCR) initiates adaptive immunity and its perturbation may results in autoimmunity. The plasma membrane scaffolding protein LAT acts as a central organizer of the TCR signaling machinery to activate many functional pathways. LAT-deficient mice develop an autoimmune syndrome but the mechanism of this pathology is unknown. In this work we have compared global...
متن کاملLAT The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation
Despite extensive study, several of the major components involved in T cell receptor-mediated signaling remain unidentified. Here we report the cloning of the cDNA for a highly tyrosine-phosphorylated 36-38 kDa protein, previously characterized by its association with Grb2, phospholipase C-gamma1, and the p85 subunit of phosphoinositide 3-kinase. Deduced amino acid sequence identifies a novel i...
متن کاملLAT Coordinate System
The hardware and software designs need a clear, consistent and universally accepted definition of the coordinate system for the LAT. This note specifies the global LAT instrument coordinate system; the terminology, numbering, and orientation of detector planes in the TKR and CAL; and tower numbering, the local tower coordinate systems, and detector element numbering within a tower. The conventi...
متن کاملLAT Indoor MIMO-VLC
Visible Light Communications (VLC) is an innovative technology that uses the visible spectrum for high-speed data communications. In this paper we investigate the use of MIMO in the design of luminaires supporting VLC and, specifically, in enabling localization and high data rate services. Localization and transmission appear as two different problems in the communication system; however, the f...
متن کاملGLAST LAT silicon tracker
The Large Area Telescope (LAT) on the Gamma-ray Large-Area Space Telescope (GLAST) mission is designed to provide unprecedented sensitivity in the exploration of the gamma-ray sky. Gamma rays with energy above 10 MeV are detected via the pair conversion process, using a precision silicon tracker-converter and a hodoscopic CsI calorimeter. Charged cosmic rays are rejected by a tiled plastic-scin...
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ژورنال
عنوان ژورنال: Sprawy Międzynarodowe
سال: 2021
ISSN: 0038-853X
DOI: 10.35757/sm.2020.73.3.05