Zingiber zerumbet (L.) Smith Hexane Crude Extract Caused DNA Damage on Leptospira spp.
نویسندگان
چکیده
Numerous attempts have been made to control leptospirosis by using chemoprophylaxis, but with limited success. The present study was done investigate the antileptospiral potential of hexane, ethyl acetate and methanol extracts Zingiber zerumbet rhizomes. were assayed for activity broth microdilution method against Leptospira interrogans (serovar Batavie, Canicola, Australis) biflexa serovar Patoc. Z. hexane extract exhibited activity, IC50 values 248 μg/mL L. 125 Australis, 15.63 Batavie 109 However, both did not show any distinct activity. Since showed DNA-damaging properties this tested according their IC25 that specific each serovars. determined treating selected spp. subjecting its DNA electrophoresis analysis on agarose gels. results demonstrated had towards Patoc as proven appearance fragmented We conclude could inhibit growth Australis through thus, be a agent. Further studies are needed an agent in vivo rat models leptospirosis.
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ژورنال
عنوان ژورنال: Sains Malaysiana
سال: 2021
ISSN: ['0126-6039', '2735-0118']
DOI: https://doi.org/10.17576/jsm-2021-5010-21