Zinc Phthalocyanine Tetrasulfonate-Loaded Ag@mSiO2 Nanoparticles for Active Targeted Photodynamic Therapy of Colorectal Cancer

Colorectal cancer has high morbidity and mortality rate, with a level of metastasis recurrence due to the poor therapeutic effects. Photodynamic therapy (PDT) as an emerging clinical modality for treatment provides remarkable advantages over existing treatments by generating reactive oxygen species (ROS) through light irradiating photosensitizers (PSs) in presence oxygen. PDT can induce immunity against destruction metastases. The application nanoparticles (NPs) targeted is coming circumvent limitations associated low physiological solubility lack selectivity PS towards tumor sites. In this vitro study, we proved added value NP systems on efficacy tumor-targeting ligand. Using core/shell Ag@mSiO 2 NPs loaded ZnPcS 4 folic acid (FA), stronger cellular localization human colorectal cell line (Caco-2) was observed compared passive NC free PS. Additionally, light-induced photodynamic activation /Ag@mSiO -FA nanoconjugate (NC) elicited strong cytotoxicity effect mediated post-PDT. results also revealed that active able decrease viability remarkably 38.0% ± 4.2 *** (67.0% 7.4*) under 0.125 µM (IC 50 ). More importantly, actively NC-induced apoptosis where cycle analysis elaborated death G0 phase, indicating final NC’s 20 hr post-PDT treatment.