Zinc Oxide Nanoparticle Synergizes Sorafenib Anticancer Efficacy with Minimizing Its Cytotoxicity
نویسندگان
چکیده
منابع مشابه
Synthesis of zinc oxide nanoparticle by zinc acetate precursor and study on its catalytic properties
ZnO nanoparticles have been prepared by a simple method in a short period of time. In this synthetic method, the sample was obtained using Zn(CH3COO)2·2H2O and a new template of hexamine salt. Their crystalline structure and morphology were studied by XRD and SEM. The optical properties of the sample were studied by UV–visible spectroscopy. The absorption spectr...
متن کاملSynthesis of zinc oxide nanoparticle by zinc acetate precursor and study on its catalytic properties
ZnO nanoparticles have been prepared by a simple method in a short period of time. In this synthetic method, the sample was obtained using Zn(CH3COO)2·2H2O and a new template of hexamine salt. Their crystalline structure and morphology were studied by XRD and SEM. The optical properties of the sample were studied by UV–visible spectroscopy. The absorption spectr...
متن کاملSorafenib synergizes with metformin in NSCLC through AMPK pathway activation
The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in ...
متن کاملReduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy
BACKGROUND Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initi...
متن کاملEnhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation
BACKGROUND Development of anticancer drugs is challenging. Indeed, much research effort has been spent in the development of new drugs to improve clinical outcomes with minimal toxicity. We have previously reported that a formulation of lipid gold porphyrin nanoparticles reduced systemic drug toxicity when compared with free gold porphyrin. In this study, we investigated the delivery and treatm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2020
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2020/1362104