Zinc-Dependent Interaction between JAB1 and Pre-S 2 Mutant Large Surface Antigen of Hepatitis B Virus and Its Implications for Viral Hepatocarcinogenesis

Synergistic Interaction Between Aflatoxin and Hepatitis B Virus in Hepatocarcinogenesis

Horizontal transmission of a hepatitis B virus surface antigen mutant.

The envelope protein of hepatitis B virus (HBV) is referred to as the HBV surface antigen (HBsAg) (8). The antigenic “a” determinant is located from residue 124 to 147 of HBsAg and is involved in eliciting antibody production. Neutralizing antibodies (anti-HBs) target the “a” determinant and generally lead to the disappearance of HBV (1). The coexistence of HBsAg and anti-HBs has been associate...

Expression of S and pre s2 Hepatitis B Surface Antigens in Mammalian Cos-7 Cell Line

Hepatitis B virus (HBV) is a serious global health problem. The development of a safe and effective vaccinewould help infection prevention. Previous hepatitis B vaccine production involved the isolation of the noninfectious particle from chronic HBV carriers. DNA recombinant technology has been used for vaccineproduction without having been contaminated with blood-born infectious ag...

Hepatitis B virus and hepatocarcinogenesis.

Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the most important predictor of hepatocarcinogenesis in HB surface antigen positive patients. We reviewed the mechanism of hepatocarcinogenesis on molecular level with a special emphasis on the role of X-protein. Hepatitis B X-protein communicates with host targets and disturbs cellular functions in...

Relationship between hepatitis B DNA Viral load in the liver and it\'s histology in patient with chronic hepatitis B

Background: Serial measurement of  hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods:  Thirty patients with chronic anti-Hbe positive ...