Zeptomole Electrochemical Detection of Metallothioneins

Zeptomole Electrochemical Detection of Metallothioneins

BACKGROUND Thiol-rich peptides and proteins possess a large number of biological activities and may serve as markers for numerous health problems including cancer. Metallothionein (MT), a small molecular mass protein rich in cysteine, may be considered as one of the promising tumour markers. The aim of this paper was to employ chronopotentiometric stripping analysis (CPSA) for highly sensitive ...

An Electrochemical Detection of Metallothioneins at the Zeptomole Level in Nanolitre Volumes

An Electrochemical Detection of Metallothioneins at the Zeptomole Level in Nanolitre VolumesWe report on improvement of the adsorptive transfer stripping technique (AdTS) coupled with the differential pulse voltammetry Brdicka reaction to determine a thiol-protein. The current technique has been unable to generate reproducible results when analyzing very low sample volumes (nanolitres). This ob...

Selective visual detection of TNT at the sub-zeptomole level.

Realizing the limits of sensitivity, while maintaining selectivity, is an ongoing quest. Among the multitude of requirements, national security, early detection of diseases, safety of public utilities, and radiation prevention are some of the areas in need of ultralow detection. Structural, functional, and electronic features of nanomaterials are used to develop reliable analytical methods. Sev...

An Electrochemical Sensor Based on Nickel Oxides Nanoparticle/ Graphene Composites for Electrochemical Detection of Epinephrine

The combination of graphene and nickel oxide nanoparticles yields nanostructured electrochemical sensor formed a novel kind of structurally uniform and electrocatalytic activity material. In cyclic voltammetry studies, in the presence of epinephrine, nickel oxide / graphene  composite modified electrode shows a significantly higher current response for epinephrine oxidation. Based on differenti...

Electrochemical Detection Of