منابع مشابه
Mutant and Transgenic Zebrafish in Modeling eurobehavioral Disorders
Zebrafish have traditionally been used as effective genetic and developmental models in biomedical research. Recently, the scope and utility of zebrafish in biomedical research has been further expanded with the implementation of new genetic techniques aimed at developing translational models of human pathogenesis. Additionally, screens measuring specific neurobehavioral and developmental pheno...
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The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate ...
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For many years, zebrafish have been the prototypical model for studies in developmental biology. In recent years, zebrafish has emerged as a powerful model system to study infectious diseases, including viral infections. Experiments conducted with herpes simplex virus type-1 in adult zebrafish or in embryo models are encouraging as they establish proof of concept with viral-host tropism and pos...
متن کاملMouse Models for Blistering Skin Disorders
Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes. This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia...
متن کاملKeratins and skin disorders.
The association of keratin mutations with genetic skin fragility disorders is now one of the best-established examples of cytoskeleton disorders. It has served as a paradigm for many other diseases and has been highly informative for the study of intermediate filaments and their associated components, in helping to understand the functions of this large family of structural proteins. The kerati...
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ژورنال
عنوان ژورنال: Dermatology Online Journal
سال: 2016
ISSN: 1087-2108
DOI: 10.5070/d3228032189