ZAC in GtoPdb v.2023.1
نویسندگان
چکیده
The zinc-activated channel (ZAC, nomenclature as agreed by the NC-IUPHAR Subcommittee for Zinc Activated Channel) is a member of Cys-loop family that includes nicotinic ACh, 5-HT3, GABAA and strychnine-sensitive glycine receptors [2, 3, 5]. likely to exist homopentamer 4TM subunits form an intrinsic cation selective equipermeable Na+, K+ Cs+, but impermeable Ca2+ Mg2+ [5]. ZAC displays constitutive activity can be blocked tubocurarine, TTFB high concentrations Although denoted ZAC, more potently activated H+ Cu2+, with greater lesser efficacy than Zn2+, respectively Orthologs human ZACN gene are present in wide range mammalian genomes, notably not mouse or rat genomes. 3].
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f83/2023.1