Ylide?Functionalized Diisopropyl Phosphine (prYPhos): A Ligand for Selective Suzuki?Miyaura Couplings of Aryl Chlorides
نویسندگان
چکیده
The ylide-functionalized diisopropyl phosphine (prYPhos) promotes Pd-catalyzed Suzuki-Miyaura couplings of aryl chlorides and bromides with arylboronic acids. Using Pd2(dba)3/prYPhos as the catalyst K2CO3 base, various (hetero)biaryls were synthesized in 45–98% yields at mild reaction conditions, tolerating sensitive functional groups steric hindrance. electron rich, sterically demanding ligand induces a high selectivity for halides versus triflate. Chloroaryl triflates selectively coupled chloride, leaving inherently more reactive triflate place.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2022
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202200321