Y-Chromosome Microdeletions: A Review of Prevalence, Screening, and Clinical Considerations
نویسندگان
چکیده
منابع مشابه
The prevalence of Y chromosome microdeletions in Pakistani infertile men
BACKGROUND Microdeletions of the azoospermia factor locus of the long arm of Y chromosome are an etiological factor of severe oligozoospermia or azoospermia. OBJECTIVE The aim of this study was to investigate the prevalence of Y-chromosome microdeletions in AZF region and their role in infertility in Pakistani population. MATERIALS AND METHODS The type of deletions in AZF locus were detecte...
متن کاملPrevalence of Y chromosome microdeletions in infertile Tunisian men.
Yq microdeletions are the leading genetic cause of male infertility and its detection in clinically relevant for appropriate genetic counseling. The objective of this study was to determine the frequency of Y microdeletion in a group of Tunisian infertile men and to compare the prevalence of these abnormalities with other countries and other Tunisian reported series. Totally, 105 Tunisian idiop...
متن کاملMultiplex PCR Screening of Y Chromosome Microdeletions in Azoospermic Patients
Objective To develop a multiplex PCR protocol for routine screening of microdeletions on the Y chromosome Methods Five multiplex sets were established and Y chromosome microdeletions screening were carried out in 26 azoospermic men who undertook ICSI and 30 azoospermic men who undertook testicular biopsy. Results In 56 azoospermic men, 5 patients were found with AZFc/DAZ microdeletions, 2 patie...
متن کاملHigh Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
BACKGROUND Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity. METHODS In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in...
متن کاملScreening for Y chromosome microdeletions in 226 Slovenian subfertile men.
BACKGROUND The objective of this study was to estimate the frequency of Y chromosome microdeletions in the Slovenian population of infertile men and to analyse the consequences of mutation in respect to clinical severity and prognosis. METHODS In a controlled clinical study at the university-based medical genetics service and infertility clinic, 226 infertile men undergoing ICSI were tested. ...
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ژورنال
عنوان ژورنال: The Application of Clinical Genetics
سال: 2021
ISSN: 1178-704X
DOI: 10.2147/tacg.s267421