XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
نویسندگان
چکیده
منابع مشابه
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plas...
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We report the genome sequence of Xenorhabdus szentirmaii DSM16338 (4.84 Mb), a symbiont of the entomopathogenic nematode Steinernema rarum. This strain produces antimicrobial activity.
متن کاملCrystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.
Chlorination of natural products is often required for their biological activity; notable examples include vancomycin, the last-ditch antibiotic. It is now known that many chlorinated natural products are made not by haloperoxidases, but by FADH2-dependent halogenases. The mechanism of the flavin-containing enzymes is obscure and there are no structural data. Here, crystals of PrnA (tryptophan ...
متن کاملA novel halogenase gene from the pentachloropseudilin producer Actinoplanes sp. ATCC 33002 and detection of in vitro halogenase activity.
A novel halogenase gene (halB) was isolated from a cosmid library of the pentachloropseudilin producer Actinoplanes sp. ATCC 33002. The halogenase has high identity (55%) to the flavin-dependent monodechloroaminopyrrolnitrin-3 halogenase from pyrrolnitrin biosynthesis and to the halogenases PltM and PltA (35% and 28%, respectively) involved in pyoluteorin biosynthesis. The enzyme has no sequenc...
متن کاملXenorhabdus luminescens (DNA hybridization group 5) from human clinical specimens.
An unusual isolate from a human leg wound was identified as Xenorhabdus luminescens. This finding led to the discovery or isolation of four additional strains, two from blood and two from wounds. Three of the five strains were from patients in San Antonio, Tex. Three strains were studied by DNA-DNA hybridization (S1 nuclease-trichloroacetic acid method) and were 77 to 100% related to each other...
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ژورنال
عنوان ژورنال: AMB Express
سال: 2019
ISSN: 2191-0855
DOI: 10.1186/s13568-019-0898-y