XNGNR1-dependent neurogenesis mediates early neural cell death
نویسندگان
چکیده
منابع مشابه
XNGNR1-dependent neurogenesis mediates early neural cell death
Early neural cell death is programmed cell death occurring within proliferating and undifferentiated neural progenitors. Little is known about the regulation and role of early neural cell death. In Xenopus embryos, primary neurogenesis is disrupted following the inhibition of early neural cell death, indicating that it is required for normal primary neurogenesis. Here we show that early neural ...
متن کاملNeurogenesis and apoptotic cell death.
As recently as a decade ago, it seemed inconceivable to most neuroscientists that new neurons could be born routinely in the adult mammalian brain (neurogenesis) and that neurons and other brain cells die by committing a form of cell suicide (apoptosis). Both fields have evolved into large research enterprises that continue to revolutionize how we think about limiting cell injury and cell death...
متن کاملActivation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death
BACKGROUND Alzheimer's disease (AD) is an age related progressive neurodegenerative disorder. One of the reasons for Alzheimer's neuropathology is the generation of large aggregates of Aß42 that are toxic in nature and induce oxidative stress, aberrant signaling and many other cellular alterations that trigger neuronal cell death. However, the exact mechanisms leading to cell death are not clea...
متن کاملCell death in early neural development: beyond the neurotrophic theory.
The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted recognition of the cell death that occurs at earlier stages of neural development, affecting proliferating neural precursor cells and young neuroblasts. In this article, we briefly present observations supporting the occurrence of programmed cell...
متن کاملCaspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats.
Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of caspase enzymes mediating apoptosis. To determine the time course of SMC death an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2005
ISSN: 0925-4773
DOI: 10.1016/j.mod.2004.12.010