Xenograft Model for Identifying Chemotherapeutic Agents against Papillomaviruses

Chemotherapeutic agents against pathogenic animal trypanosomes

Trypanosomoses are protozoan diseases, affecting both human and animals, and mainly found in tropical Africa, Latin America and Asia. In Africa, trypanosomes produce serious diseases in human beings such as West and East Sleeping Sickness caused by T. brucei gambiense and T. brucei congolense respectively, while in the Americas T. cruzi causes the Chagas disease. Other species of Trypanosoma af...

A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

Relevant preclinical mouse models are crucial to screen new therapeutic agents for acute myeloid leukemia (AML). Current in vivo models based on the use of patient samples are not easy to establish and manipulate in the laboratory. Our objective was to develop robust xenograft models of human AML using well-characterized cell lines as a more accessible and faster alternative to those incorporat...

Chemotherapeutic Agents for External Parasites

Because some antibiotics have proved active in certain parasitic infections, there appears to be good prospect that this rapidly growing and meagerly tested class of chemotherapeutic agents (there are already some 4,000 known antibiotics!) will some day provide efficient treatments for some of the parasitic diseases of livestock and poultry. Antibiotics are especially useful for combating bacte...

Herbicides as Potential Chemotherapeutic Agents Against Parasitic Protozoa

MICs and MBCs of chemotherapeutic agents against Renibacterium salmoninarum.

The efficacies of 21 chemotherapeutic agents for controlling bacterial kidney disease were evaluated. The bactericidal and/or bacteriostatic effects of these drugs were tested against 11 Renibacterium salmoninarum strains with different origins. The most effective compounds displaying both bacteriostatic and bactericidal activity for all the isolates were tetracycline and erythromycin, with MIC...