Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
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منابع مشابه
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric aci...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms7555