WWOX drives UV/cold shock‐induced bubbling cell death whereas without WWOX cells pop out
نویسندگان
چکیده
منابع مشابه
WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway
1Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan, ROC 2Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan, ROC 3Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan, Taiwan, ROC 4Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan, ...
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Malignant cancer cells frequently secrete significant amounts of transforming growth factor beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing to target organs. In a non-canonical signaling, TGF-β binds membrane hyaluronidase Hyal-2 for recruiting tumor suppressors WWOX and Smad4, and the resulting Hyal-2/WWOX/Smad4 complex is accumulated in the nucleus to enhance SMAD...
متن کاملUV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures
When COS7 fibroblasts and other cells were exposed to UVC irradiation and cold shock at 4°C for 5 min, rapid upregulation and nuclear accumulation of NOS2, p53, WWOX, and TRAF2 occurred in 10-30 min. By time-lapse microscopy, an enlarging gas bubble containing nitric oxide (NO) was formed in the nucleus in each cell that finally popped out to cause "bubbling death". Bubbling occurred effectivel...
متن کاملWWOX loss activates aerobic glycolysis
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating thi...
متن کاملHYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response
Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are essential for the metabolism of hyaluronan (HA). Hyal-2 deficiency is associated with chronic thrombotic microangiopathy with hemolytic anemia in mice due to over accumulation of high molecular size HA. HYAL-2 is essential for...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.646.4