WSB1 Involvement in Prostate Cancer Progression

Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene target numerous oncoproteins, its dysregulation can contribute to tumor progression by abnormal activation targeted oncogenes. Using data from the Cancer Genome Atlas, we tested possible involvement in PC progression. A multi-dimensional scaling (MDS) model was applied clarify association expression with other key such as c-myc, ERG, Enhancer Zeste 1 2 (EHZ1 EZH2), WNT10a, WNT 10b. An increased associated higher grades worse prognosis. It also positively related EZH1, EZH2, WNT10b. Moreover, MDS showed central role influencing genes location on map. Our study first show link between involved progression, suggesting novel for This network EZH2 through WNT/β-catenin may have an important suggested high unfavorable prognosis our analysis.