Wound dressings as growth factor delivery platforms for chronic wound healing
نویسندگان
چکیده
Introduction: Years of tissue engineering research have clearly demonstrated the potential integrating growth factors (GFs) into scaffolds for regeneration, a concept that has recently been applied to wound dressings. The old dressings only take passive role in healing now overtaken, and advanced which can an active part healing, are current interest.Areas covered: In this review we will focus on recent strategies delivery GFs sites with emphasis different approaches used achieve fine tuning spatial temporal concentrations therapeutic efficacy.Expert opinion: use accelerate reduce scar formation is considered feasible approach patients high risk infections complications. integration micro – nanotechnologies could be key overcome inherent instability offer adequate control over release rate. Many investigations led encouraging outcomes various vitro vivo models, it expected some these technologies satisfy clinical needs enter commercialization.
منابع مشابه
Wound healing dressings and drug delivery systems: a review.
The variety of wound types has resulted in a wide range of wound dressings with new products frequently introduced to target different aspects of the wound healing process. The ideal dressing should achieve rapid healing at reasonable cost with minimal inconvenience to the patient. This article offers a review of the common wound management dressings and emerging technologies for achieving impr...
متن کاملContinuous epidermal growth factor delivery in corneal epithelial wound healing.
PURPOSE To investigate the effects of a single prolonged exposure to recombinant epidermal growth factor on the healing of anterior keratotomy wounds in New Zealand white rabbits. METHODS After wounding, eyes were perfused for 1, 2, 4, and 8 hours with either epidermal growth factor solution at a concentration of 50 micrograms/ml or balanced saline solution using a Morgan therapeutic lens (Mo...
متن کاملGrowth Factors in Chronic Wound Healing
©2013 Regents of the University of California and VerusMed, with permission. Unauthorized reproduction of Wound Care Update is strictly prohibited. Growth substances (cytokines and growth factors) are soluble signaling proteins affecting the process of normal wound healing. Cytokines govern the inflammatory phase that clears cellular and extracellular matrix debris. Wound repair is controlled b...
متن کاملSuperficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy Under Limited Access and Conventional Dressings
BACKGROUND Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. This study determines superficial burn wound healing with intermittent n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Opinion on Drug Delivery
سال: 2021
ISSN: ['1742-5247', '1744-7593']
DOI: https://doi.org/10.1080/17425247.2021.1867096