Worm variation made accessible

Worm variation made accessible

In Caenorhabditis elegans, the recent advances in high-throughput quantitative analyses of natural genetic and phenotypic variation have led to a wealth of data on genotype phenotype relations. This data has resulted in the discovery of genes with major allelic effects and insights in the effect of natural genetic variation on a whole range of complex traits as well as how this variation is dis...

Protos 7.0: Simulation Made Accessible

Many consider simulation to be a highly specialist activity: it is difficult to undertake and is even more difficult to understand its outcomes. The new version of the business process modeling tool Protos attempts to more closely integrate modeling and simulation facilities into one tool. The assumed benefit is that business professionals may more easily undertake simulation experiments when t...

Commercial web sites made accessible for all

LTE radio analytics made easy and accessible Citation

Despite the rapid growth of next-generation cellular networks, researchers and end-users today have limited visibility into the performance and problems of these networks. As LTE deployments move towards femto and pico cells, even operators struggle to fully understand the propagation and interference patterns affecting their service, particularly indoors. This paper introduces LTEye, the first...

Wild worm embryogenesis harbors ubiquitous polygenic modifier variation

Embryogenesis is an essential and stereotypic process that nevertheless evolves among species. Its essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in the wild-type but that enhances or suppresses the effects of rare disruptions to gene function. Here, we adapted a classical modifier screen to interrogate the alleles segregating in natural population...