WNT signaling in bone development and homeostasis
نویسندگان
چکیده
منابع مشابه
Wnt Signaling in Bone
Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonica...
متن کاملNoncanonical Wnt Signaling in Bone
The Wnt family of proteins plays essential roles conserved from flies to human in many developmental processes including cell fate specification, polarity, migration and proliferation. It has becoming increasingly clear that Wnt proteins activate multiple intracellular signaling cascades to achieve the diverse biological functions. One such cascade that has been most intensely studied to date i...
متن کاملWnt and the Wnt signaling pathway in bone development and disease.
Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two major branches: the canonical pathway and the n...
متن کاملWnt signaling in bone development and disease: making stronger bone with Wnts.
The skeleton as an organ is widely distributed throughout the entire vertebrate body. Wnt signaling has emerged to play major roles in almost all aspects of skeletal development and homeostasis. Because abnormal Wnt signaling causes various human skeletal diseases, Wnt signaling has become a focal point of intensive studies in skeletal development and disease. As a result, promising effective t...
متن کاملWnt Signaling in Embryonic Development
Researchers studying the Wnt pathway frequently like to joke that ‘Wnts do everything’, and that this fact keeps us all in business. Over time, this claim has become less facetious, as the number of known roles for Wnt signaling has grown rapidly. Following on from the first identified functions of Wnts in embryonic tissue patterning and cell proliferation, these signals and their multiple down...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Developmental Biology
سال: 2014
ISSN: 1759-7684
DOI: 10.1002/wdev.159