WITHDRAWN: Predicting multidrug resistance-related protein and P-glycoprotein expression with technetium-99m tetrofosmin mammoscintigraphy

Usefulness of Technetium-99m-Tetrofosmin Mammoscintigraphy to Predict Expressions of P-Glycoprotein and Multidrug Resistance Related Protein: A Preliminary Report

Received 4/4/2002; revised 4/16/2002; accepted 4/23/2002. For correspondence or reprints contact: Chia-Hung Kao, M.D., Department of Nuclear Medicine, China Medical College Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan. Tel: (886)4-22052121 ext. 3475, Fax: (886)4-22023442, E-mail: [email protected] Purpose: The aim of this study was to evaluate the relationship between the tumor uptake of...

P-Glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings.

The purpose of this study was to retrospectively study 48 patients with infiltrating ductal breast cancer to evaluate the relationship between the degree of accumulation of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) and P-glycoprotein (Pgp) or multidrug resistance-related protein (MRP) expression in breast cancer tissues. Before surgery or biopsy, all 48 patients underwent scintimammogr...

Rapid miniaturized chromatography for technetium-99m-tetrofosmin.

UNLABELLED The purpose of this investigation was to develop and evaluate a new and rapid miniaturized chromatography system that would accurately assess the radiochemical purity of 99mTc-tetrofosmin without the problems of solvent ratios and time requirements associated with the manufacturer's recommended procedure. METHODS The migration of the radiochemical components of 99mTc-tetrofosmin wa...

Multidrug Resistance Protein (P-Glycoprotein; MDR1)

Technetium-99m-tetrofosmin imaging of lung cancer: relationship with histopathology.

Tc-99m-tetrofosmin is an agent to delineate cancer. To elucidate the usefulness of Tc-99m-tetrofosmin scintigraphy, we analyzed the relationship between the uptake of Tc-99m-tetrofosmin and histopathology in patients with lung cancer. SPECT studies were conducted twice: 15 minutes (early scan), and 60 minutes (delayed scan), after intravenous injection of 740 MBq Tc-99m-tetrofosmin. We calculat...