منابع مشابه
The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing.
Phagocytosis is a primary defense program orchestrated by monocytes/macrophages. Unregulated phagocytosis can lead to pathological conditions. In the current study we have demonstrated that Wnt5a stimulates phagocytosis through PI3 kinase-Rac1 and lipid-raft-dependent processes. Wnt5a-mediated augmentation in phagocytosis is suppressed by blocking expression of the putative Wnt5a receptor Frizz...
متن کاملWingless signalling: More about the Wingless morphogen
Recent work on pattern formation in the Drosophila embryo reveals a new mechanism which shapes the gradient of the secreted morphogen, Wingless: Wingless protein is degraded more rapidly on one side of its source than on the other.
متن کاملApical Localization of wingless Transcripts Is Required for Wingless Signaling
Many developing and adult tissues are comprised of polarized epithelia. Proteins that are asymmetrically distributed in these cells are thought to be localized by protein trafficking. Here we show that the distribution and function of the signaling protein Wingless is predetermined by the subcellular localization of its mRNA. High-resolution in situ hybridization reveals apical transcript local...
متن کاملHedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning.
A fundamental concept in development is that secreted molecules such as Wingless (Wg) and Hedgehog (Hh) generate pattern by inducing cell fate. By following markers of cellular identity posterior to the Wg- and Hh-expressing cells in the Drosophila dorsal embryonic epidermis, we provide evidence that neither Wg nor Hh specifies the identity of the cell types they pattern. Rather, they maintain ...
متن کاملA Wingless Flight
PLoS Biology | http://biology.plosjournals.org The Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling pathway that plays important roles in normal development and cancer, from worms and flies to mice and humans. Two papers, identifying the first components of this pathway, initiated the active research field of Wnt/Wg signal transduction and profoundly influenced my scientific c...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2001
ISSN: 1471-0072,1471-0080
DOI: 10.1038/35073031