منابع مشابه
Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker.
Wnts and bone morphogenetic proteins (BMPs) are signaling elements that are crucial for a variety of events in animal development. In Drosophila, Wingless (Wg, a Wnt ligand) and Decapentaplegic (Dpp, a BMP homolog) are thought to function through distinct signal transduction pathways and independently direct the patterning of the wing. However, recent studies suggest that Mothers against Dpp (M...
متن کاملWingless signalling: More about the Wingless morphogen
Recent work on pattern formation in the Drosophila embryo reveals a new mechanism which shapes the gradient of the secreted morphogen, Wingless: Wingless protein is degraded more rapidly on one side of its source than on the other.
متن کاملAn unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.
Wnt/beta-catenin signals orchestrate cell fate and behavior throughout the animal kingdom. Aberrant Wnt signaling impacts nearly the entire spectrum of human disease, including birth defects, cancer, and osteoporosis. If Wnt signaling is to be effectively manipulated for therapeutic advantage, we first must understand how Wnt signals are normally controlled. Naked cuticle (Nkd) is a novel and e...
متن کاملWingless and the argosomes
Wingless and the argosomes ignaling proteins may set up gradients by moving in membrane fragments, dubbed argosomes by Suzanne Eaton and colleagues (Eaton first observed the structures when she was studying apical–basal sorting of proteins that have glycophosphatidylinositol (gpi) tails. " It was this completely random observation several years ago, " she says. " When we saw this we just droppe...
متن کاملNaked Singularity and Thunderbolt
We consider quantum theoretical effects of the sudden change of the boundary conditions which mimics the occurrence of naked singularities. For a simple demonstration, we study a massless scalar field in (1 + 1)-dimensional Minkowski spacetime with finite spatial interval. We calculate the vacuum expectation value of the energy-momentum tensor and explicitly show that singular wave or thunderbo...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2000
ISSN: 1465-7392,1476-4679
DOI: 10.1038/35004067