منابع مشابه
Wilson disease at a single cell level: intracellular copper trafficking activates compartment-specific responses in hepatocytes.
Wilson disease (WD) is a severe hepato-neurologic disorder that affects primarily children and young adults. WD is caused by mutations in ATP7B and subsequent copper overload. However, copper levels alone do not predict severity of the disease. We demonstrate that temporal and spatial distribution of copper in hepatocytes may play an important role in WD pathology. High resolution synchrotron-b...
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the Single-Molecule Level with Nanovesicle Trapping Jaime J. Benı́tez,† Aaron M. Keller,† Patrick Ochieng,‡ Liliya A. Yatsunyk,§ David L. Huffman,*,‡ Amy C. Rosenzweig,§ and Peng Chen*,† Department of Chemistry and Chemical Biology, Cornell UniVersity, Ithaca, New York 14853, Department of Chemistry, Western Michigan UniVersity, Kalamazoo, Michigan 49008, and Departments of Biochemistry, Molecul...
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One of the most rapidly advancing areas in genomics in recent years has been the explosion of platforms to assess properties at the single-cell level. The driving force behind these advancements has been a renaissance of sorts in how we think about the architecture and heterogeneity present in a population of cells (1, 2). While these concepts are not new, the advancement of technologies to ass...
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The timing of a cellular event often hides critical information on the process leading to the event. Our ability to measure event times in single cells along with other quantities allow us to learn about the drivers of the timed process and its downstream effects. In this review, we cover different types of events that have been timed in single cells, methods to time such events and types of an...
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A single cell creates surprising heterogeneity in a multicellular organism. While every organismal cell shares almost an identical genome, molecular interactions in cells alter the use of DNA sequences to modulate the gene of interest for specialization of cellular functions. Each cell gains a unique identity through molecular coding across the DNA, RNA, and protein conversions. On the other ha...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.114447