Wilms' tumor gene 1 (WT1) in endometrial carcinoma
نویسندگان
چکیده
منابع مشابه
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.
Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia. The WT1 gene was originally defined as a tumor suppressor gene, but we proposed that it was, on the ...
متن کاملMutations in the Wilms' tumor gene WT1 in leukemias.
The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36 acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise...
متن کاملOverexpression of the Wilms' tumor gene WT1 in esophageal cancer.
BACKGROUND The Wilms' tumor gene WT1 is overexpressed in various kinds of solid cancers. However, it remains unclear whether WT1 is expressed in esophageal squamous cell carcinoma. MATERIALS AND METHODS Expression of the WT1 gene was examined by real-time RT-PCR in 12 esophageal squamous cell carcinoma (ESCC) and by immunohistochemistry in 9 of these 12 and another 29. RESULTS Real-time RT-...
متن کاملCancer immunotherapy targeting Wilms' tumor gene WT1 product.
The Wilms' tumor gene WT1 is expressed at high levels in leukemic blast cells in most acute myeloid and lymphoblastic leukemias. In myelodysplastic syndrome, WT1 mRNA expression levels increase along with disease progression; thus, WT1 mRNA is a tumor marker for leukemic blast cells. WT mRNA is also expressed at high levels in various types of solid cancers, including cancers of the lung, breas...
متن کاملExpression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.
BACKGROUND The product of the Wilms' tumor gene, WT1 protein, is a tumor antigen for various kinds of cancer, and WT1 peptide-based cancer immunotherapy is widely anticipated as a new possibility for cancer treatment. The aim of this study was to investigate the expression of WT1 from quantitative and morphological perspectives in oral squamous cell carcinoma (OSCC), the most widespread maligna...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2008
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2008.08.032