Wideband photoacoustic imaging in vivo with complementary frequency conventional ultrasound transducers

Photoacoustic (PA) signals are typically broadband in nature. The bandwidth of PA depends on the size distribution underlying chromophores. Typically, conventional ultrasound (US) transducers, designed for pulse-echo imaging, have limited bandwidth, which reduces their sensitivity to signal. rejection out-of-band impairs image reconstruction, leading loss details. Visualization biological structures, particular deep targets with a range sizes requires large acquisition bandwidth. In this work, we combine data acquired two US array probes complementary frequency bands order widen However, transducers also differ and combining results misrepresentation signal strengths. Therefore, article report novel PA-based method calibrate relative sensitivities transducers. proposed was applied various scenarios, including imaging vascular structures vivo. Results revealed that it is feasible visualize varying widely while information dual addition, application compensation ratios avoids scheme by accounting differences both during acquisition.