Why clinical translation cannot succeed without failure

Why clinical translation cannot succeed without failure

The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and demonstrating the limits of proven drugs. A wider recognition of these benefits will help the biomedical research enterprise to take full advantage ...

Climate change policy failures: why conventional mitigation approaches cannot succeed.

Why the EU cannot succeed The doomed community model of European Integration

"The metaphor of the 'House of Europe' awakens fear of sinister homeliness: the French on the first floor, the Dutch without curtains at the windows, and a German caretaker who urges Italians to sort the rubbish properly and flush the toilet ecologically". 1 "There is no single civil right which the European Union could guarantee. Europe is a soap-box speech, a kind of fair-weather ideology."

Why relevant chemical information cannot be exchanged without disclosing structures

Both society and industry are interested in increasing the safety of pharmaceuticals. Potentially dangerous compounds could be filtered out at early stages of R&D by computer prediction of biological activity and ADMET characteristics. Accuracy of such predictions strongly depends on the quality & quantity of information contained in a training set. Suggestion that some relevant chemical inform...

Why managed care cannot contain hospital costs--without rationing.