Whole brain N-acetylaspartate concentration is conserved throughout normal aging
نویسندگان
چکیده
منابع مشابه
Longitudinal whole-brain N-acetylaspartate concentration in healthy adults.
BACKGROUND AND PURPOSE Although NAA is often used as a marker of neural integrity and health in different neurologic disorders, the temporal behavior of WBNAA is not well characterized. Our goal therefore was to establish its normal variations in a cohort of healthy adults over typical clinical trial periods. MATERIALS AND METHODS Baseline amount of brain NAA, Q(NAA), was obtained with nonloc...
متن کاملSerial whole-brain N-acetylaspartate concentration in healthy young adults.
Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was ...
متن کاملWhole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge.
BACKGROUND AND PURPOSE Although NAA is often used as a marker of neuronal health and integrity in neurologic disorders, its normal response to physiologic challenge is not well-established and its changes are almost always attributed exclusively to brain pathology. The purpose of this study was to test the hypothesis that the neuronal cell marker NAA, often used to assess neuronal health and in...
متن کاملWhole-Brain N-Acetylaspartate Concentration Comparison of Young and Elderly Healthy: Evidence for Brain Durability
Introduction: An estimated 40 million Americans are currently 65 years of age or older, with that number expected to grow to 70 million by 2030 (1). Since several neurological conditions, especially Alzheimer’s Disease (AD) and the broad spectrum of ischemic disorders, afflict the elderly, the burden of these diseases to healthcare delivery will soon become staggering. Although it has been show...
متن کاملReproducibility of three whole-brain N-acetylaspartate decline cohorts in relapsing-remitting multiple sclerosis.
BACKGROUND AND PURPOSE The cross-sectional rate of whole-brain N-acetylaspartate (NAA, a neuronal cell marker) loss in clinically similar relapsing-remitting multiple sclerosis (RRMS) patients has recently been shown to fall into 3 distinct decline rate strata. Our goal was to test the reproducibility of this observation in a new cohort of RRMS patients. MATERIALS AND METHODS Sixteen serial p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2012
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2011.12.008