Whole body autoradiographic studies on the distribution of 3H-labeled penfluridol (3H-TLP-607) in mice and rats.
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Autoradiographic distribution of 14C-labeled 3H-imidazo[4,5-f]quinoline-2-amines in mice.
The highly mutagenic heterocyclic amines, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), are formed during heating of protein-rich foods. In order to gain information about the distribution and fate of IQ and MeIQ in vivo, a whole-body autoradiographic study of i.v.-injected 14C-labeled IQ and MeIQ has been performed in male NMRI, pregnant N...
متن کاملDistribution of [3H]-3-hydroxykynurenine in mice.
The distribution of 3-hydroxykynurenine, a tryptophan metabolite that is suspected of being carcinogenic, was studied in mice. After s.c. administration of [3H]-3-hydroxykynurenine into male BALB/c X DBA/2 F1 mice, the distribution of 3H was investigated by whole-body autoradiography and radioactivity measurement. At 30 and 60 min after injection, 3H was distributed mainly in the kidneys, pancr...
متن کاملNicotinic Binding in Rat Brain: Autoradiographic Comparison of [3H]Acetylcholine, [3H]Nicotine, and [‘251]-~-Bungarotoxin1
Three radioligands have been commonly used to label putative nicotinic cholinoceptors in the mammalian central nervous system: the agonists [3H]nicotine and [3H]acetylcholine (C3H]ACh-in the presence of atropine to block muscarinic receptors), and the snake venom extract, [1251]-a-bungarotoxin([‘251]BTX), which acts as a nicotinic antagonist at the neuromuscular junction. Binding studies employ...
متن کاملDistribution of 3H-labeled staphylococcal alpha-toxin and a toxin fragment in mice.
Staphylococcal alpha-toxin and a toxin fragment were labeled with N-succinimidyl[2,3-3H]propionate. The labeled compounds retained greater than 95% biological activity. The distribution of labeled staphylococcal alpha-toxin and alpha-toxin fragment after intravenous administration to BALB/c mice was studied with whole-body and microautoradiography. The animals were divided into three groups tha...
متن کاملQuantitative Autoradiographic Study of Labeled Rna in Rabbit Optic Nerve after Intraocular Injection of [3h]uridine
The distribution of labeled RNA in the optic nerve of the rabbit was studied by quantitative ultrastructural autoradiography after the intraocular injection of [(3)H]uridine. The highest density of silver grains related to [(3)H]RNA (27-40 grains/100 microm(2)) was found in glial cell perikarya; a slightly lower density was present in the glial nuclei (19-20 grains/100 microm(2)). Axons (4-5 gr...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1974
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.22.1996