White Matter Hyperintensity-Associated Blood-Brain Barrier Disruption and Vascular Risk Factors
نویسندگان
چکیده
منابع مشابه
White matter hyperintensity penumbra.
BACKGROUND AND PURPOSE White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear. Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci o...
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Cerebral white matter hyperintensities (WMHs) have been associated with vascular risk factors, both of which are under genetic influence. We examined in a monozygotic twin sample whether the association between vascular risk and WMHs is influenced by overlapping genetic factors. We included 195 cognitively normal monozygotic twins (age = 70 ± 7 years), including 94 complete pairs. Regional WMH ...
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Background and Purpose—White matter hyperintensities have been associated with increased risk of stroke, cognitive decline, and dementia. Chronic kidney disease is a risk factor for vascular disease and has been associated with inflammation and endothelial dysfunction, which have been implicated in the pathogenesis of white matter hyperintensities. Few studies have explored the relationship bet...
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ژورنال
عنوان ژورنال: Journal of Stroke and Cerebrovascular Diseases
سال: 2018
ISSN: 1052-3057
DOI: 10.1016/j.jstrokecerebrovasdis.2017.09.026