Whipple Disease Research Accelerates

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Whipple Disease Research Accelerates Kenneth

The face of Whipple disease is changing rapidly. The disease was originally described in 1907 by the pathologist George Hoyt Whipple [1], but it was not until 1961 that electron microscopic studies showed it definitively to be caused by bacteria [2, 3]. The causative organism could not be cultivated, and the cell wall ultrastructure was considered ambiguous, so there was even uncertainty as to ...

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Whipple disease associated with giardiasis.

We tested 53 fixed duodenal biopsy samples from 25 patients with Whipple disease for the presence Giardia and 6 fresh duodenal biopsy samples for Giardia duodenalis DNA by polymerase chain reaction (PCR). We also used histological examination and PCR assay to determine the prevalence of G. duodenalis in duodenal biopsy samples from 150 control patients without Whipple disease. Three of 25 patie...

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MR of cerebral Whipple disease.

A case of cerebral Whipple disease is reported. MR findings of the brain are discussed in relation to neuropathologic lesions reported previously. Repeated MR investigations may serve as a valuable tool to evaluate long-term efficacy of treatment in cerebral Whipple disease.

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Pulmonary hypertension associated with Whipple disease.

References 1 Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. Clin Chest Med 2011; 32: 1–13. 2 Melot C, Naeije R. Pulmonary vascular diseases. Compr Physiol 2011; 1: 593–619. 3 Cutts BA, Dasgupta D, Hunt BJ. New directions in the diagnosis and treatment of pulmonary embolism in pregnancy. Am J Obstet Gynecol 2013; 208: 102–108. 4 Pernot J, Puzenat E, Magy-Bertrand N, et al. Detection...

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Whipple disease of the central nervous system.

In 1907, George H. Whipple reported the clinical manifestations and autopsy findings for a patient with the disease that now bears his name [1]. Nearly all of the cardinal clinical manifestations of this disorder—including arthralgias, abdominal pain, fever, diarrhea, malabsorption, weight loss, and cough—were evident in this first patient reported. On the basis of observations of fat and fatty...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 2011

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/jir213