Where are G-quadruplexes located in the human transcriptome?
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It has been hypothesized that G-quadruplexes can sequester the 3' end of the telomere and prevent it from being extended by telomerase. Here we purify and characterize stable, conformationally homogenous human telomeric G-quadruplexes, and demonstrate that human telomerase is able to extend parallel, intermolecular conformations in vitro. These G-quadruplexes align correctly with the RNA templa...
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ژورنال
عنوان ژورنال: NAR Genomics and Bioinformatics
سال: 2020
ISSN: 2631-9268
DOI: 10.1093/nargab/lqaa035