منابع مشابه
When more is not more
oosting the function of a learning protein jams the brain with too much information, according to Ype Elgersma (Erasmus MC, Rotterdam, Netherlands), Alcino Silva (University of California, Los Angeles, CA), and colleagues. The result is a cautionary tale for those seeking to develop learning drugs. The team created mice lacking two inhibitory phosphorylation sites on CaMKII. Wild-type CaMKII is...
متن کاملWhen Is More Not Better?
It is often assumed that when sensing in autonomous robot navigation, the more measurements taken, the better. In many cases, this is indeed true. However, we have found that in an outdoor, unstructured environment where the number of possible measurements one can take is limited and error is not normally distributed, additional measurements may cause more harm than good. These “rogue” measurem...
متن کاملWhen size is not important any more
Wireless phone companies, especially with number portability, sell a product that is less and less different, that is to say, a commodity. That is the reason scale economies play a very important role in this market. Given that it is not possible to make a large margin on the service that they offer, companies must focus their strategies on saving costs. Moreover, the more clients a company has...
متن کاملWhen Less is More
engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...
متن کاملWhen more is better
Nutrition support of critically ill patients with sepsis is one of the most debated issues among intensivists. The latest international sepsis guidelines recommend the prescription of a low volume of feeds through gastric or intestinal enteral nutrition (EN) for 7 days after admission to the ICU. The data to support such recommendations are scarce, and large trials are needed to clarify this is...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1595rr1