منابع مشابه
When centromeres fill in for telomeres
Klebba and Galletta et al. reveal that the scaffold protein Asterless (Asl) regulates centriole duplication by controlling turnover of the kinase Plk4. Cells must duplicate their centri-oles once, and only once, per cell cycle. In interphase, the master regulator of centriole duplication, Plk4, triggers its own destruction by homodimerizing and phosphorylating itself. In mitosis, however, the p...
متن کاملPlant chromosomes from end to end: telomeres, heterochromatin and centromeres.
Recent evidence indicates that heterochromatin in plants is composed of heterogeneous sequences, which are usually composed of transposable elements or tandem repeat arrays. These arrays are associated with chromatin modifications that produce a closed configuration that limits transcription. Centromere sequences in plants are usually composed of tandem repeat arrays that are homogenized across...
متن کاملMeiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe.
In fission yeast meiotic prophase, telomeres are clustered near the spindle pole body (SPB; a centrosome-equivalent structure in fungi) and take the leading position in chromosome movement, while centromeres are separated from the SPB. This telomere position contrasts with mitotic nuclear organization, in which centromeres remain clustered near the SPB and lead chromosome movement. Thus, nuclea...
متن کاملCell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast
Fluorescence in situ hybridization (FISH) shows that fission yeast centromeres and telomeres make up specific spatial arrangements in the nucleus. Their positioning and clustering are cell cycle regulated. In G2, centromeres cluster adjacent to the spindle pole body (SPB), while in mitosis, their association with each other and with the SPB is disrupted. Similarly, telomeres cluster at the nucl...
متن کاملTelomeres and centromeres have interchangeable roles in promoting meiotic spindle formation
Telomeres and centromeres have traditionally been considered to perform distinct roles. During meiotic prophase, in a conserved chromosomal configuration called the bouquet, telomeres gather to the nuclear membrane (NM), often near centrosomes. We found previously that upon disruption of the fission yeast bouquet, centrosomes failed to insert into the NM at meiosis I and nucleate bipolar spindl...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2084iti2