منابع مشابه
What Renders TAU Toxic
TAU is a microtubule-associated protein that under pathological conditions such as Alzheimer's disease (AD) forms insoluble, filamentous aggregates. When 20 years after TAU's discovery the first TAU transgenic mouse models were established, one declared goal that was achieved was the modeling of authentic TAU aggregate formation in the form of neurofibrillary tangles. However, as we review here...
متن کاملToxic tau aggregation in AD.
The pathological hallmarks of Alzheimer’s disease (AD) are extracellular β-amyloid deposition and intracellular tau inclusions. While β-amyloid deposition does not correlate with clinical progression of AD, the diffusion of neurofibrillary tangles (NFTs) from the entorhinal cortex to the neocortex, followed by neuronal and synapse loss, matches well with the clinical progression of AD symptomat...
متن کاملFyn-Tau-Amyloid: A Toxic Triad
The axonal protein tau and amyloid beta-peptide (Abeta) are key players in the pathogenesis of Alzheimer's disease, and tau mediates Abeta toxicity, but it is not clear how. Ittner et al. (2010) now report an unexpected physiological function for tau in neuronal dendrites that may explain how tau mediates Abeta toxicity.
متن کاملWhat makes silica toxic?
Published data suggest that particle charge could be related to its toxicity. Respirable particles containing silica were therefore collected in foundries and their charge measured. These particles carried high levels of positive charge that were related to low humidity. Incubating these particles with pulmonary macrophages from mice produced detectable activities of collagenase, a precursor of...
متن کاملFrom tau phosphorylation to tau aggregation: what about neuronal death?
Tau pathology is characterized by intracellular aggregates of abnormally and hyperphosphorylated tau proteins. It is encountered in many neurodegenerative disorders, but also in aging. These neurodegenerative disorders are referred to as tauopathies. Comparative biochemistry of the tau aggregates shows that they differ in both tau isoform phosphorylation and content, which enables a molecular c...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2013
ISSN: 1664-2295
DOI: 10.3389/fneur.2013.00072