What is the optimal dosage for intravitreal bevacizumab for retinopathy of prematurity?

Intravitreal low-dosage bevacizumab for retinopathy of prematurity.

PURPOSE To report on the therapeutic effect of intravitreal low-dose bevacizumab for treatment for retinopathy of prematurity (ROP). METHODS The single-centre retrospective, non-comparative case series study included all infants who consecutively underwent intravitreal injection of 0.375 mg bevacizumab (0.03 ml) under light sedation in topical anaesthesia as therapy of ROP in zone I or zone I...

Intravitreal bevacizumab for retinopathy of prematurity: Considerations for informed consent.

Retinopathy of prematurity (ROP), a disease of abnormal blood vessel proliferation in the retina, is estimated to account for approximately 20% of cases of pediatric blindness worldwide. Guidelines set by the American Academy of Pediatrics, the American Academy of Ophthalmology, and the American Association for Pediatric Ophthalmology and Strabismus outline criteria for the screening and treatm...

Efficacy of intravitreal bevacizumab for zone-II retinopathy of prematurity.

PURPOSE To assess the effect of intravitreal bevacizumab for Type 1 retinopathy of prematurity (ROP) in zone II ROP. METHODS We conducted a randomized clinical trial. Preterm infants with a gestational age less than 34 weeks or birthweight less than 2000 g were examined at 4 weeks chronological age or 31 weeks postmenstrual age (whichever was later). Preterm infants with Zone-II/Stage 2 or 3 ...

Hypotension Associated With Intravitreal Bevacizumab Therapy for Retinopathy of Prematurity.

Intravitreal bevacizumab therapy in preterm infants for retinopathy of prematurity (ROP) can be associated with hypotension. We report twin preterm infants who developed hypotension within 1 day after intravitreal bevacizumab therapy for ROP. Before receiving the medication, their clinical statuses were stable and similar. The dose, procedure, and premedication were the same; however, twin B pr...

Bevacizumab for retinopathy of prematurity.