What is it that we really do?

Pleomorphic xanthoastrocytoma: what do we really know about it?

BACKGROUND Pleomorphic xanthoastrocytomas (PXA) may recur and demonstrate aggressive clinical behavior with a mortality rate between 15% and 20%. To the authors' knowledge, no histopathologic features currently are known to reliably predict recurrence or tumor progression. METHODS The study was based on 71 cases with available information regarding clinical and therapeutic data and follow-up....

Evolvability: What Is It and How Do We Get It?

Cytogenetic biodosimetry: what it is and how we do it.

Dicentric assay is the international gold standard for cytogenetic biodosimetry after radiation exposure, despite being very labour-intensive, time-consuming, and highly expertise-dependent. It involves the identification of centromeres and structure of solid-stained chromosomes and the enumeration of dicentric chromosomes in a large number of first-division metaphases of cultured T lymphocytes...

What Is It that Drives Dynamics: We Don't Believe in Ghosts, Do We?

In this contribution the focus is on a philosophical and historical reflection on dynamics, in relation to the basic assumptions underlying state-determined systems, following [1]. A basic assumption of a state-determined system is that some of the state properties of the previous state in a sense anticipate on the changed state properties in the current state. This idea plays an important role...

Subclinical atherosclerosis: what it is, what it means and what we can do about it

Atherosclerosis is a chronic, progressive, inflammatory disease with a long asymptomatic phase. Disease progression can lead eventually to the occurrence of acute cardiovascular events such as myocardial infarction, unstable angina pectoris and sudden cardiac death. While the disease is still in a subclinical stage, however, the presence of atherosclerosis can be identified by several methods, ...