What causes an RNA-DNA hybrid to compromise genome integrity?
نویسندگان
چکیده
منابع مشابه
RNA Binding Proteins and Genome Integrity
Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites...
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MOTIVATION While there are numerous programs that can predict RNA or DNA secondary structures, a program that predicts RNA/DNA hetero-dimers is still missing. The lack of easy to use tools for predicting their structure may be in part responsible for the small number of reports of biologically relevant RNA/DNA hetero-dimers. RESULTS We present here an extension to the widely used ViennaRNA Pa...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2019
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2019.102660