What a polyclonal antibody sees in von Willebrand factor
نویسندگان
چکیده
منابع مشابه
Antibody-Based Protection of von Willebrand Factor Degradation.
Recently, Bartoli et al. (1) reported on the use of doxycycline to reduce ADAMTS-13-mediated von Willebrand factor degradation during supraphysiological shear stress. We have read their article with interest, noticing reference in their discussion to one of our recent publications that appeared in Thrombosis and Haemostasis (2). However, we would like to correct some significant misinterpretati...
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von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD). To gain a better understanding of vWF interactions in vivo, the use of zebrafish as a model is ideal because of the trans...
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The adhesive protein von Willebrand factor contributes to platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury. In the last 2 years, there has been considerable progress in explaining the biologic properties of von Willebrand factor. The three-dimensional structure of specific domains has been explained, with the demonstration of distin...
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The normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor activity). Removal of greater than 95% of the sialic acid from this protein by neuraminidase did not affect the von Willebrand factor or procoagulant activity. However, oxidation of the penultimate galactose of the asialo Factor V...
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The life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of the VWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by observations that VWF clearance is a relatively common com...
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ژورنال
عنوان ژورنال: Thrombosis Research
سال: 2008
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2007.05.015