Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

BACKGROUND: Lifelong consumption of a Western-style diet is risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset age-related diseases prolong life span, however, extent to which this depends on type poorly understood. OBJECTIVE: To study whether feeding affects aging benefits DR. METHODS: Mice fed (ad libitum DR) were compared those standard DR). Survival several endocrine parameters analyzed. RESULTS: resulted in increased adiposity, elevated triglyceride levels plasma, higher homeostatic model assessment-insulin resistance resting rate mice group. This was accompanied by reduced survival DR irrespective improved abovementioned parameters. CONCLUSIONS: restricted led parameters, ad Interestingly, comparable groups, suggesting that food intake rather than composition play more important role promoting longevity/survival.