WCN23-0273 IDENTIFICATION AND EXPRESSION LEVEL OF CHAPERONES IN RENAL AMYLOID DEPOSITS OF DIFFERENT AMYLOIDOSIS

Amyloidosis is a protein conformational disease caused by the deposition of extracellular insoluble fibrils which derived from misfolded precursor proteins. The kidney organ most commonly involved in amyloidosis, common types renal amyloidosis include immunoglobulin light chain (AL), amyloid A (AA) and leukocyte chemotactic factor 2 (ALECT2). Previous studies revealed that deposits are often accompanied chaperones, including serum P component (SAP), apolipoprotein E (ApoE) A-IV (ApoA-IV), have been suggested to play crucial roles formation progression fibrils, regarded as therapeutic targets clinical trials.