Ways to predict interstitial lung disease in patients with systemic sclerosis: results of an observational study

In patients with systemic sclerosis (SSc), interstitial lung disease (ILD) is a factor in the decline of functional capacity up to disability and also leading cause death. Therefore, one most important tasks treatment this group not only detect involvement respiratory system, but predict likelihood its development. Objective : study possibility predicting development ILD advanced SSc. Material methods . The included 79 SSc (mean age 64.4±11.5 years; 94.9% women) from Registry myositis, Mixed Connective Tissue Diseases (РЕМИССиС) who underwent high-resolution computed tomography (HRCT) lungs. Classification trees (CTr) were constructed widespread using CHAID algorithm (exhaustive). All tested for antibodies against Scl-70 (anti-Scl-70), CENP-B (anti-CENP-B), PmScl (anti-PmScl). Results discussion signs according HRCT detected 53 patients. Fibrotic (34.2%) cellular (15.2%) types nonspecific pneumonia common, common was less frequent (11.4%).The presence (involvement more than 20% parenchyma) significantly associated detection any autoantibodies, except anti-centromere antibodies, an increase pulmonary artery systolic pressure, decrease forced vital capacity, diffusing lungs, blood oxygen saturation at rest, all parameters six-minute walk test (6MWT), complaints shortness breath. addition, extensive diffuse without skin manifestations. establishing CTr, it found that unlikely individuals able 440 m 6MWT had neither anti-Scl-70 nor anti-PmScl. Significant associations between radiological pattern disease-specific antibodies. Conclusion data conjunction results testing SSc-specific autoantibodies provide very accurate prediction extent ILD. It advisable include these indicators screening monitoring