Water Soluble Polymers for Pharmaceutical Applications

Pharmaceutical Applications of Plasticized Polymers

The modern pharmaceutical technology is not conceivable without plasticized polymers. The pharmaceutical applications of polymers range from packaging materials or auxiliary substances in conventional dosage forms to membranes or matrices modifying and controlling the drug release characteristics in therapeutic systems. Recently, a great variety of plasticized polymeric systems have been studie...

Probing alamethicin channels with water-soluble polymers

Channel access resistance has been measured to estimate the characteristic size of a single ion channel. We compare channel conductance in the presence of nonpenetrating water-soluble polymers with that obtained for polymer-free electrolyte solution. The contribution of the access resistance to the total alamethicin channel resistance is 10% for first three open channel levels. The open alameth...

Water soluble polymers in tumor targeted delivery.

The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, wh...

Micro- and Nano- encapsulation of Water- and Oil-soluble Actives for Cosmetic and Pharmaceutical Applications

Skin, hair and mucosal surfaces are useful targets for the delivery of active compounds, botanicals and, importantly, drugs. Encapsulation provides an invaluable tool to the cosmetic and/or pharmaceutical formulator, providing great flexibility in the choice of delivery mechanisms and excipients that can be used. Dispersions of solid lipid nanoparticles (SLNs) were prepared using biodegradable ...

Pharmaceutical Formulation for Poorly Water Soluble Camptothecin Analogues