Water-Gated Proton Transfer Dynamics in Respiratory Complex I
نویسندگان
چکیده
منابع مشابه
Symmetry-related proton transfer pathways in respiratory complex I.
Complex I functions as the initial electron acceptor in aerobic respiratory chains of most organisms. This gigantic redox-driven enzyme employs the energy from quinone reduction to pump protons across its complete approximately 200-Å membrane domain, thermodynamically driving synthesis of ATP. Despite recently resolved structures from several species, the molecular mechanism by which complex I ...
متن کاملElectrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.
Complex I serves as the primary electron entry point into the mitochondrial and bacterial respiratory chains. It catalyzes the reduction of quinones by electron transfer from NADH, and couples this exergonic reaction to the translocation of protons against an electrochemical proton gradient. The membrane domain of the enzyme extends ∼180 Å from the site of quinone reduction to the most distant ...
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The role of water molecules in assisting proton transfer (PT) is investigated for the proton-pumping protein ferredoxin I (FdI) from Azotobacter vinelandii. It was shown previously that individual water molecules can stabilize between Asp(15) and the buried [3Fe-4S](0) cluster and thus can potentially act as a proton relay in transferring H(+) from the protein to the μ(2) sulfur atom. Here, we ...
متن کاملWater dynamics and proton transfer in nafion fuel cell membranes.
The dynamics of water and its effect on proton transport kinetics in Nafion membranes are compared at several hydration levels. Nafion is the most widely used polyelectrolyte membrane in fuel cells. Ultrafast infrared spectroscopy of the O-D stretch of dilute HOD in H2O provides a probe of the local environment and hydrogen bond network dynamics of water confined in the hydrophilic regions of N...
متن کاملVoltage-gated proton channels and other proton transfer pathways.
Proton channels exist in a wide variety of membrane proteins where they transport protons rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules present in the protein, but its function is regulated by titratable groups on critical amino acid residues in the pathway. All proton channels conduct protons by a hydrogen-bonded chain mechanism in which the proton hop...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2020
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.0c02789