منابع مشابه
Watching kinetochores sweat
A simple way to get cleavage o partition cellular components into dividing daughter cells, the spindle apparatus induces the formation of a cleavage furrow, but results conflict about which specific components are required for this process. By physically dissecting the spindle apparatus in grasshopper spermato-cytes, Alsop and Zhang now show on page 383 that bundled microtubules are the only st...
متن کاملKinetochores
Not to be confused with1⁄4 centrosomes. But it’s OK to confuse them with centromeres. The centromere is the chromosomal domain where the kinetochore is assembled. Genetically speaking, the centromere is the locus necessary to segregate chromosomes. In many species, the centromere is also defined cytologically as the primary constriction visible on condensed chromosomes (the intersection point o...
متن کاملKip3 clusters kinetochores.
During mitosis chromosome segregation relies on the action of microtubules within the mitotic spindle. Each chromosome is attached to spindle microtubules via its sister kinetochores, the proteinacious complexes found at opposite sides of its centromere.1 The subset of microtubules that becomes attached to the kinetochores is referred to as kinetochore microtubules (kMTs). While each kinetochor...
متن کاملKip3-ing kinetochores clustered.
Metaphase is the brief and highly conspicuous period during cell division where chromosomes become positioned at the spindle equator through the process of " congression ". it is generally believed that congression promotes accurate chromosome segregation during anaphase, and this logic has driven research over several decades to identify the underlying mechanisms. Recent studies have demonstra...
متن کاملRan at kinetochores.
The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic spindles with respect to chromosomes. In addit...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1623iti5