Warning on Diuretic Use

An early warning on early warning systems!

Warning: Risks from Concomitant Use with Opioids

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death [see Warnings, Drug Interactions].  Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.  Limit dosages and durations to the minimum required.  Follow patie...

Increased incidence of diuretic use in critically ill obese patients.

OBJECTIVE Sodium retention occurs commonly in cardiac and liver disease, requiring the administration of diuretics to restore fluid balance. Whether obesity is associated with sodium retention has not been fully evaluated. METHODS In a large single-center cohort of critically ill patients, we evaluated whether admission body mass index was associated with the administration of either oral or ...

Fluid balance, diuretic use, and mortality in acute kidney injury.

BACKGROUND AND OBJECTIVES Management of volume status in patients with acute kidney injury (AKI) is complex, and the role of diuretics is controversial. The primary objective was to elucidate the association between fluid balance, diuretic use, and short-term mortality after AKI in critically ill patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Using data from the Fluid and Catheter Tr...

A review of diuretic use in dialysis patients.

Diuretics are commonly prescribed to manage various conditions in the general population. They can continue to play a role in dialysis patients to manage extracellular fluid volume and hypertension and to reduce the tendency to hyperkalemia. Nevertheless, diuretics are often stopped when patients commence dialysis. Several studies have shown that preserved residual renal function in dialysis pa...