Warm Red Blood Cell Autoantibodies and the Direct Antiglobulin Test Revisited
نویسندگان
چکیده
منابع مشابه
Harmless Pregnancy-Induced Warm Autoantibodies to Red Blood Cells
BACKGROUND There is little information concerning the development and significance of autoantibodies (aab) to red blood cells (RBCs) during pregnancy. METHODS Unselected pregnant women were routinely screened for the presence of unexpected antibodies to RBCs using standard techniques. RESULTS Between 2009 and 2013, 153,612 pregnant women were tested. The antibody screening test was positive...
متن کاملErythrocyte Membrane Proteins Reactive With IgG (Warm-Reacting) Anti-Red Blood Cell Autoantibodies: 11. Antibodies Coprecipitating
In our initial immunochemical study of the red blood cell (RBCI membrane proteins targeted in 20 cases of warmantibody autoimmune hemolytic anemia (AHA), RBC eluates of 6 patients mediated immunoprecipitation (IP) of both band 3 and glycophorin A (GPA). This dual IP pattern had previously been observed with murine monoclonal antibodies (MoAbs) against the high frequency blood group antigen, Wrb...
متن کاملThe Direct Antiglobulin (coombs) Test in Megaloblastic Anaemia.
Folic acid deficiency with the picture of a megaloblastic bone marrow may develop in haemolytic anaemia, and, on the other hand, both vitamin B(12) and folic acid deficiency may produce signs of haemolysis. As the correct interpretation of a positive antiglobulin reaction associated with megaloblastic erythropoiesis is particularly important, the effect of deficiency of vitamin B(12) and folic ...
متن کاملAllogeneic red blood cell adsorption for removal of warm autoantibody.
Adsorption studies are usually required to confirm or rule out the presence of underlying alloantibodies in samples containing warm autoantibody. Allogeneic adsorptions are necessary if the patient has been recently transfused. Most commonly, allogeneic adsorptions are performed using a trio of phenotyped reagent red blood cells to rule out clinically significant alloantibodies to common antige...
متن کاملClinical relevance of silent red blood cell autoantibodies.
The diagnosis of autoimmune hemolytic anemia (AIHA) is based on the evidence of anemia, hemolysis and the detection of red blood cell (RBCs) autoantibodies. The absence of detectable RBC autoantibodies does not always exclude autoimmune hemolysis. Conversely, the presence of RBC autoantibodies is not always associated with hemolytic anemia. Silent RBC autoantibodies have been detected in health...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173
DOI: 10.1309/lrwa-xya2-033u-0bdv