Warfarin Pharmacogenetics: Challenges and Opportunities for Clinical Translation

Warfarin Pharmacogenetics: Challenges and Opportunities for Clinical Translation

Candidate gene studies The recognition of genetic regulation of warfarin response has stimulated efforts aimed at quantifying this influence. The bulk of the evidence supports the influence of single nucleotide polymorphisms (SNPS) in two genes; Cytochrome P450 2C9 (CYP2C9; codes for the main enzyme involved in warfarin metabolism) and Vitamin K epoxide reductase complex1 (VKORC1; encodes the v...

Pharmacogenetics – Challenges and Opportunities Ahead

Pharmacogenetics, the study of the influence of genetic variation on drug response, and pharmacogenomics, the genome-wide and multifactorial extension of the term (the inclusive code PGx is used from here on), are central to the modern concept of personalized medicine. Although a " person-alized " approach has always been a hallmark of good medical practice, the new aspect is the extensive use ...

Warfarin pharmacogenetics meets clinical use.

ence is sufficient to disrupt the nucleolar structure.9 Similarly, the anticancer peptide CIGB-300 leads to nucleolar disassembly and apoptosis, most likely through its capability to bind NPM1.10 Because AML cells carrying the NPM1 mutation are depleted of wild-type NPM1 protein in their nucleolar pool (because of haploinsufficiency and cytoplasmic dislocation through formation of heterodimers ...

Warfarin Pharmacogenetics: A Rising Tide for its Clinical Value Running title: Johnson, Clinical utility of warfarin pharmacogenetics

Pharmacogenetics of tacrolimus: ready for clinical translation?

Tacrolimus (Tac) exhibits an interindividual pharmacokinetic variability that affects the dose required to reach the target concentration in blood. Tac is metabolized by two enzymes of the cytochrome P450 family, CYP3A5 and CYP3A4. The effect of the CYP3A5 genotype on Tac bioavailability has been demonstrated, and the main determinant of this pharmacogenetic effect is a single-nucleotide polymo...