Warburg Effect and Mitochondrial Metabolism in Skin Cancer
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چکیده
منابع مشابه
“Warburg Effect” and Mitochondrial Metabolism in Skin Cancer
Skin cancer is the most common type of cancer in the United States, with an increasing annual rate. Defining the mechanism of skin cancer malignancy and progression is the first step towards skin cancer prevention and therapy. “Warburg Effect” describes the preference of glycolysis and lactate fermentation rather than oxidative phosphorylation for energy production in cancer cells, which also p...
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Department of Chemistry, University of Pennsylvania, USA Department of Physiology and Integrated Biosystems, College of Medicine, Inje University, Busan, Korea Systems Immunology Laboratory, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Department of Internal Medicine, College of Medicine, Inje University and Busan Paik Hospital Organ Transplantation Center, Busan, Kor...
متن کاملCancer metabolism: the Warburg effect today.
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with co...
متن کاملRole of MicroRNAs in the Warburg Effect and Mitochondrial Metabolism in Cancer
Obtaining sufficient energy is a critical issue for cells to survive. In contract to normal counterparts, most cancer cells rely on aerobic glycolysis, a metabolic phenotype referred as the Warburg effect (Gatenby et al., 2004). A shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis is a unique biochemical characteristic of cancer cells (Hsu et al., 2008). This alter...
متن کاملRole of microRNAs in the Warburg effect and mitochondrial metabolism in cancer.
Metabolism lies at the heart of cell biology. The metabolism of cancer cells is significantly different from that of their normal counterparts during tumorigenesis and progression. Elevated glucose metabolism is one of the hallmarks of cancer cells, even under aerobic conditions. The Warburg effect not only allows cancer cells to meet their high energy demands and supply biological materials fo...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2014
ISSN: 2157-2518
DOI: 10.4172/2157-2518.s4-002