VWD diagnosis: improved

VWD type 1: a calculated diagnosis.

Tosetto and colleagues have developed a mathematical method to quantify the odds of having type 1 von Willebrand Disease based on a person's family history, bleeding score, and VWF level.

Provisional criteria for the diagnosis of VWD type 1.

The Role of Bleeding History and Clinical Markers for the Correct Diagnosis of VWD

Quantification of the bleeding severity by use of bleeding assessment tools (BAT) and bleeding score (BS) has been consistently shown to improve the clinical diagnosis of von Willebrand disease (VWD) while helping researchers establish phenotype/genotype correlations. Subjects with a BS equal or higher than 3 may be consider having a bleeding tendency, and should be referred for a laboratory in...

Differential identification of PT-VWD from type 2B VWD and GP1BA nomenclature issues.

management of VTE in the UK rather than postpartum treatment, which uses the well-established regimens used in the non-pregnant patient. The optimal low molecular weight heparin (LMWH) dosing regimen in pregnancy has not been clearly established. Collectively, the two studies showed wide variability in treatment schedules between and within centres, without any evidence for superiority of one r...

VWF propeptide in defining VWD subtypes.

In this issue of Blood, Sanders and coworkers define the pathophysiology of types 1, 2, and 3 von Willebrand disease (VWD) in the Willebrand in the Netherlands (WiN) study by using the ratios of von Willebrand factor propeptide (VWFpp) or factor VIII activity to VWF antigen.