VRAC s swallow platinum drugs

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VRACs swallow platinum drugs.

Platinum-based drugs such as cisplatin and carboplatin are on the WHO model list of essential medicines, as highly effective chemotherapeutic drugs for the treatment of various solid tumors. These drugs react with purine residues in DNA, thereby causing DNA damage, inhibition of cell division, and eventually cell death. However, the mechanisms whereby platinum-based drugs enter cancer cells rem...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2015

ISSN: 0261-4189,1460-2075

DOI: 10.15252/embj.201593357